Optimization and Interpretation of Serial QuantiFERON Testing to Measure Acquisition of Mycobacterium tuberculosis Infection.

ABSTRACT:

Rationale

Conversion from a negative to positive QuantiFERON-TB test is indicative of Mycobacterium tuberculosis (Mtb) infection, which predisposes individuals to tuberculosis disease. Interpretation of serial tests is confounded by immunological and technical variability.

Objectives

To improve the consistency of serial QuantiFERON-TB testing algorithms and provide a data-driven definition of conversion.

Methods

Sources of QuantiFERON-TB variability were assessed, and optimal procedures were identified. Distributions of IFN-γ response levels were analyzed in healthy adolescents, Mtb-unexposed control subjects, and patients with pulmonary tuberculosis.

Measurements and main results

Individuals with no known Mtb exposure had IFN-γ values less than 0.2 IU/ml. Amon

SUBMITTER: Nemes E 

PROVIDER: S-EPMC5620669 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature