High-Dose Vitamin D₃ during Tuberculosis Treatment in Mongolia. A Randomized Controlled Trial.

ABSTRACT:

Rationale

Existing trials of adjunctive vitamin D in the treatment of pulmonary tuberculosis (PTB) are variously limited by small sample sizes, inadequate dosing regimens, and high baseline vitamin D status among participants. Comprehensive analyses of the effects of genetic variation in the vitamin D pathway on response to vitamin D supplementation are lacking.

Objectives

To determine the effect of high-dose vitamin D₃ on response to antimicrobial therapy for PTB and to evaluate the influence of single-nucleotide polymorphisms (SNPs) in vitamin D pathway genes on response to adjunctive vitamin D₃.

Methods

We conducted a clinical trial in 390 adults with PTB in Ulaanbaatar, Mongolia, who were randomized to receive four biweekly doses of 3.5 mg (1

SUBMITTER: Ganmaa D 

PROVIDER: S-EPMC5620670 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature