¹⁸F-Deoxyfluorination of Phenols via Ru π-Complexes.

ABSTRACT: The deficiency of robust and practical methods for ¹⁸F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted ¹⁸F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.

SUBMITTER: Beyzavi MH 

PROVIDER: S-EPMC5621004 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature