Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis.

ABSTRACT:

Background/objectives

The relationship between folate and colorectal neoplasia remains controversial. We examined the association between serum folate concentrations and colorectal adenomas in a case-control study of Korean adults and conducted a meta-analysis.

Subjects/methods

Our case-control study included 113 pairs of case and control who underwent colonoscopy and provided blood samples. We used multivariable conditional logistic regression models to obtain the odds ratios and 95% confidence interval (CIs). For meta-analysis, we identified the relevant studies by searching the PubMed database up to February 2017, included our case-control study and combined the study-specific relative risks (RRs) using a random-effects model.

Results

In this case-control study, we

SUBMITTER: Park YM 

PROVIDER: S-EPMC5621365 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature