Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression.

ABSTRACT: Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depression and how they adapt in response to stress has not been addressed. We identify two discrete circuits of parvalbumin-positive (PV) neurons in the ventral pallidum (VP) projecting to either the lateral habenula or ventral tegmental area contributing to depression. We find that these populations undergo different electrophysiological adaptations in response to social defeat stress, which are normalized by antidepressant treatment. Furthermore, manipulation of each population

SUBMITTER: Knowland D 

PROVIDER: S-EPMC5621481 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature