MR Elastography-derived Stiffness: A Biomarker for Intervertebral Disc Degeneration.

ABSTRACT: Purpose To determine the repeatability of magnetic resonance (MR) elastography-derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and their relationship with IVD degeneration and subject age. Materials and Methods In a cross-sectional study, in vivo lumbar MR elastography was performed once in the morning and once in the afternoon in 47 subjects without current low back pain (IVDs = 230; age range, 20-71 years) after obtaining written consent under approval of the institutional review board. The Pfirrmann degeneration grade and MR elastography-derived shear stiffness of the nucleus pulposus and annulus fibrosus regions of all lumbar IVDs were assessed by means of principal frequency analysis. One-way analysis of variance, paired t tests, concorda

SUBMITTER: Walter BA 

PROVIDER: S-EPMC5621721 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature