Lymphatic Vessels Balance Viral Dissemination and Immune Activation following Cutaneous Viral Infection.

ABSTRACT: Lymphatic vessels lie at the interface between peripheral sites of pathogen entry, adaptive immunity, and the systemic host. Though the paradigm is that their open structure allows for passive flow of infectious particles from peripheral tissues to lymphoid organs, virus applied to skin by scarification does not spread to draining lymph nodes. Using cutaneous infection by scarification, we analyzed the effect of viral infection on lymphatic transport and evaluated its role at the host-pathogen interface. We found that, in the absence of lymphatic vessels, canonical lymph-node-dependent immune induction was impaired, resulting in exacerbated pathology and compensatory, systemic priming. Furthermore, lymphatic vessels decouple fluid and cellular transport in an interferon-dependent manner, l

SUBMITTER: Loo CP 

PROVIDER: S-EPMC5621787 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature