Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

ABSTRACT: The maintenance of peripheral naive T lymphocytes in humans is dependent on their homeostatic division, not continuing emigration from the thymus, which undergoes involution with age. However, postthymic maintenance of naive T cells is still poorly understood. Previously we reported that recent thymic emigrants (RTEs) are contained in CD31+CD25- naive T cells as defined by their levels of signal joint T cell receptor rearrangement excision circles (sjTRECs). Here, by differential gene expression analysis followed by protein expression and functional studies, we define that the naive T cells having divided the least since thymic emigration express complement receptors (CR1 and CR2) known to bind complement C3b- and C3d-decorated microbial products and, following activation, produce IL-8 (CX

SUBMITTER: Pekalski ML 

PROVIDER: S-EPMC5621870 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature