Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors.

ABSTRACT: Experimental data indicate that FOXP3+ Tregs can markedly curtail host antitumor immune responses, but the properties of human intratumoral Tregs are still largely unknown, in part due to significant methodologic problems. We studied the phenotypic, functional, epigenetic, and transcriptional features of Tregs in 92 patients with non-small-cell lung cancer, comparing the features of Tregs within tumors versus corresponding blood, lung, and lymph node samples. Intratumoral Treg numbers and suppressive function were significantly increased compared with all other sites but did not display a distinctive phenotype by flow cytometry. However, by undertaking simultaneous evaluation of mRNA and protein expression at the single-cell level, we demonstrated that tumor Tregs have a phenotype characte

SUBMITTER: Akimova T 

PROVIDER: S-EPMC5621877 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature