Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy.

ABSTRACT: The architectural integrity of tissues requires complex interactions, both between cells and between cells and the extracellular matrix. Fundamental to cell and tissue homeostasis are the specific mechanical forces conveyed by the actomyosin cytoskeleton. Here we used super-resolution imaging methods to visualize the actin cytoskeleton in the kidney glomerulus, an organized collection of capillaries that filters the blood to make the primary urine. Our analysis of both mouse and human glomeruli reveals a network of myosin IIA-containing contractile actin cables within podocyte cell bodies and major processes at the outer aspects of the glomerular tuft. These likely exert force on an underlying network of myosin IIA-negative, noncontractile actin fibers present within podocyte foot processe

SUBMITTER: Suleiman HY 

PROVIDER: S-EPMC5621879 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature