Correction of intermittent hypoxia reduces inflammation in obese subjects with obstructive sleep apnea.

ABSTRACT:

Background

In obese subjects with obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) may be linked to systemic and adipose tissue inflammation.

Methods

We obtained abdominal subcutaneous adipose tissue biopsies from OSA and non-OSA obese (BMI > 35) subjects at baseline and after 24 weeks (T1) of weight-loss intervention plus continuous positive airway pressure (c-PAP) or weight-loss intervention alone, respectively. OSA subjects were grouped according to good (therapeutic) or poor (subtherapeutic) adherence to c-PAP.

Results

At baseline, anthropometric and metabolic parameters, serum cytokines, and adipose tissue mRNA levels of obesity-associated chemokines and inflammatory markers were not different in OSA and non-OSA subjects. At T1, body weight was s

SUBMITTER: Perrini S 

PROVIDER: S-EPMC5621882 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature