Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease.

ABSTRACT:

Background

Noninvasive detection of Alzheimer's disease (AD) with high specificity and sensitivity can greatly facilitate identification of at-risk populations for earlier, more effective intervention. AD patients exhibit a myriad of retinal pathologies, including hallmark amyloid β-protein (Aβ) deposits.

Methods

Burden, distribution, cellular layer, and structure of retinal Aβ plaques were analyzed in flat mounts and cross sections of definite AD patients and controls (n = 37). In a proof-of-concept retinal imaging trial (n = 16), amyloid probe curcumin formulation was determined and protocol was established for retinal amyloid imaging in live patients.

Results

Histological examination uncovered classical and neuritic-like Aβ deposits with increased retinal Aβ42 plaq

SUBMITTER: Koronyo Y 

PROVIDER: S-EPMC5621887 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature