IL-23R-activated STAT3/STAT4 is essential for Th1/Th17-mediated CNS autoimmunity.

ABSTRACT: The factors that promote the differentiation of pathogenic T cells in autoimmune diseases are poorly defined. Use of genetically modified mice has provided insight into molecules necessary for the development of autoimmunity, but the sum of the data has led to contradictory observations based on what is currently known about specific molecules in specific signaling pathways. To define the minimum signals required for development of encephalitogenic T cells that cause CNS autoimmunity, myelin-specific T cells were differentiated with various cytokine cocktails, and pathogenicity was determined by transfer into mice. IL-6+IL-23 or IL-12+IL-23 generated encephalitogenic T cells and recapitulated the essential cytokine signals provided by antigen-presenting cells, and both IL-6 and IL-12 induc

SUBMITTER: Lee PW 

PROVIDER: S-EPMC5621925 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature