Foxp3⁺ Tregs are recruited to the retina to repair pathological angiogenesis.

ABSTRACT: Neovascular retinopathies are major causes of vision loss; yet treatments to prevent the condition are inadequate. The role of regulatory T cells in neovascular retinopathy is unknown. Here we show that in retinopathy regulatory T cells are transiently increased in lymphoid organs and the retina, but decline when neovascularization is established. The decline is prevented following regulatory T cells expansion with an IL-2/anti-IL-2 mAb complex or the adoptive transfer of regulatory T cells. Further, both approaches reduce vasculopathy (vaso-obliteration, neovascularization, vascular leakage) and alter the activation of Tmem119⁺ retinal microglia. Our in vitro studies complement these findings, showing that retinal microglia co-cultured with regulatory T cells exhibit a reductio

SUBMITTER: Deliyanti D 

PROVIDER: S-EPMC5622066 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature