Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins.

ABSTRACT: The composition of the extracellular matrix (ECM) proteins and the expression of their cognate receptors dictate cell behavior and dynamics. In particular, the interactions of ECM proteins with integrin receptors are key mediators of these cellular processes, playing a crucial role in the progression of several diseases of the liver, including inflammation, fibrosis/cirrhosis and cancer. This study establishes a modeling approach combining computation and experiments to evaluate the kinetics of integrin receptor binding to hepatic ECM proteins. ECM ligand concentration was derived from LC-MS/MS quantification of the hepatic ECM from mice exposed to chronic carbon tetrachloride (CCl₄); receptor density was derived from published literature. Mathematical models for ECM-integrin bi

SUBMITTER: Hudson SV 

PROVIDER: S-EPMC5622105 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature