Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and <i>In Vitro</i> Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses.

ABSTRACT: Neonates and especially premature infants are highly susceptible to infection but still can have a remarkable resilience that is poorly understood. The view that neonates have an incomplete or deficient immune system is changing. Human neonatal studies are challenging, and elucidating host protective responses and underlying cognate pathway biology, in the context of viral infection in early life, remains to be fully explored. In both resource rich and poor settings, human cytomegalovirus (HCMV) is the most common cause of congenital infection. By using unbiased systems analyses of transcriptomic resources for HCMV neonatal infection, we find the systemic response of a preterm congenital HCMV infection, involves a focused IFN regulatory response associated with dendritic cells. Further ana

SUBMITTER: Dantoft W 

PROVIDER: S-EPMC5622154 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature