Potential Role of Vδ2⁺ γδ T Cells in Regulation of Immune Activation in Primary HIV Infection.

ABSTRACT: Although conventional regulatory T cells (Tregs) are sufficient in controlling low residual T-cell activation in ART-treated patients, they are not efficient in controlling exaggerated immune activation associated with high levels of HIV replication in primary HIV infection (PHI). Our previous data suggested that double negative (DN) T cells including mainly γδ DN T cells play a role in the control of immune activation in PHI. Since γδ T cells are capable of exerting regulatory functions, we investigated their implication as Tregs in PHI as well as chronic HIV infection (CHI). In a cross-sectional study of 58 HIV-infected patients, in the primary and the chronic phase either ART-treated or untreated (UT), we analyzed phenotype and cytokine production of γδ T cells using flow cytometry. Cyt

SUBMITTER: Bhatnagar N 

PROVIDER: S-EPMC5622291 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature