Accurate and reproducible functional maps in 127 human cell types via 2D genome segmentation.

ABSTRACT: The Roadmap Epigenomics Consortium has published whole-genome functional annotation maps in 127 human cell types by integrating data from studies of multiple epigenetic marks. These maps have been widely used for studying gene regulation in cell type-specific contexts and predicting the functional impact of DNA mutations on disease. Here, we present a new map of functional elements produced by applying a method called IDEAS on the same data. The method has several unique advantages and outperforms existing methods, including that used by the Roadmap Epigenomics Consortium. Using five categories of independent experimental datasets, we compared the IDEAS and Roadmap Epigenomics maps. While the overall concordance between the two maps is high, the maps differ substantially in the prediction

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5622376 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature