Angiopoietin-like protein as a novel marker for liver fibrosis in chronic hepatitis B patients with normal to minimally raised ALT.

ABSTRACT:

Background

For hepatitis B patients who do not meet the treatment criteria recommended by guidelines, therapy decisions depend on hepatic histology. Angiopoietin-like protein 2 (Angptl2) is a mediator of chronic inflammation that contributes to extracellular matrix remodeling. The aim of this study was to explore the predictive value of Angptl2 as a novel biomarker of liver histology.

Methods

Hepatitis B patients with normal to minimally raised ALT were recruited. Serum Angptl2 concentrations were detected using commercial ELISA kit. The fibrosis score were assessed according to Ishak criteria. Significant fibrosis was defined as ISHAK score ≥ 3.

Results

Of 460 patients, 223 cases served as training cohort and 237 ones as validation cohort. Serum Angptl2 concentration

SUBMITTER: Deng Y 

PROVIDER: S-EPMC5622570 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature