A clinical-genetic approach to assessing cardiovascular risk in patients with CKD.

ABSTRACT:

Background

Coronary heart disease (CHD) is the primary cause of death in individuals with chronic kidney disease (CKD), but current equations for assessing coronary risk have low accuracy in this group. We have reported that the addition of a genetic risk score (GRS) to the Framingham risk function improved its predictive capacity in the general population. The aims of this study were to evaluate the association between this GRS and coronary events in the CKD population and to determine whether the addition of the GRS to coronary risk prediction functions improves the estimation of coronary risk at the earliest possible stages of kidney disease.

Methods

A total of 632 CKD patients, aged 35-74 years, who had Stage 4-5 CKD, were on dialysis, had a functioning renal transplant

SUBMITTER: Rodrigo E 

PROVIDER: S-EPMC5622901 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature