Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity.

ABSTRACT:

Objective

Roseburia hominis is a flagellated gut anaerobic bacterium belonging to the Lachnospiraceae family within the Firmicutes phylum. A significant decrease of R. hominis colonization in the gut of ulcerative colitis patients has recently been demonstrated. In this work, we have investigated the mechanisms of R. hominis-host cross talk using both murine and in vitro models.

Design

The complete genome sequence of R. hominis A2-183 was determined. C3H/HeN germ-free mice were mono-colonized with R. hominis, and the host-microbe interaction was studied using histology, transcriptome analyses and FACS. Further investigations were performed in vitro and using the TLR5KO and DSS-colitis murine models.

Results

In th

SUBMITTER: Patterson AM 

PROVIDER: S-EPMC5622956 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature