Cerebrospinal Fluid Amino Acid Profiling of Pediatric Cases with Tuberculous Meningitis.

ABSTRACT: Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of tuberculous meningitis (TBM) being the most severe manifestation. TBM is often difficult to diagnose in its early stages because of its non-specific clinical presentation. Of particular concern is that late diagnosis, and subsequent delayed treatment, leads to high risk of long-term neurological sequelae, and even death. Using advanced technology and scientific expertise, we are intent on further describing the biochemistry behind this devastating neuroinflammatory disease, with the goal of improving upon its early diagnosis. Method: We used the highly sensiti

SUBMITTER: Mason S 

PROVIDER: S-EPMC5623012 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature