Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.

ABSTRACT: ERK-dependent signaling is key to many pathways through which extracellular signals are transduced into cell-fate decisions. One conundrum is the way in which disparate signals induce specific responses through a common, ERK-dependent kinase cascade. While studies have revealed intricate ways of controlling ERK signaling through spatiotemporal localization and phosphorylation dynamics, additional modes of ERK regulation undoubtedly remain to be discovered. We hypothesized that fine-tuning of ERK signaling could occur by cysteine oxidation. We report that ERK is actively and directly oxidized by signal-generated H₂O₂ during proliferative signaling, and that ERK oxidation occurs downstream of a variety of receptor classes tested in four cell lines. Furthermore, within t

SUBMITTER: Keyes JD 

PROVIDER: S-EPMC5623068 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature