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Inhibition of Clostridium perfringens epsilon toxin by β-cyclodextrin derivatives.

ABSTRACT: Clostridium perfringens epsilon toxin (ETX) is considered as one of the most dangerous potential biological weapons. The goal of this work was to identify inhibitors of ETX using a novel approach for the inactivation of pore-forming toxins. The approach is based on the blocking of the target pore with molecules having the same symmetry as the pore itself. About 200 various β-cyclodextrin derivatives were screened for inhibitors of ETX activity using a colorimetric cell viability assay. Several compounds with dose-dependent activities at low micromolar concentrations have been identified. The same compounds were also able to inhibit lethal toxin of Bacillus anthracis.

SUBMITTER: Robinson TM

PROVIDER: S-EPMC5623079 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Inhibition of Clostridium perfringens epsilon toxin by β-cyclodextrin derivatives.

Robinson Tanisha M TM Jicsinszky Laszlo L Karginov Andrei V AV Karginov Vladimir A VA

International journal of pharmaceutics 20170725 2

Clostridium perfringens epsilon toxin (ETX) is considered as one of the most dangerous potential biological weapons. The goal of this work was to identify inhibitors of ETX using a novel approach for the inactivation of pore-forming toxins. The approach is based on the blocking of the target pore with molecules having the same symmetry as the pore itself. About 200 various β-cyclodextrin derivatives were screened for inhibitors of ETX activity using a colorimetric cell viability assay. Several c ...[more]

PMID: 28750897

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