TLR2 Plays a Key Role in Platelet Hyperreactivity and Accelerated Thrombosis Associated With Hyperlipidemia.

ABSTRACT:

Rationale

Platelet hyperreactivity, which is common in many pathological conditions, is associated with increased atherothrombotic risk. The mechanisms leading to platelet hyperreactivity are complex and not yet fully understood.

Objective

Platelet hyperreactivity and accelerated thrombosis, specifically in dyslipidemia, have been mechanistically linked to the accumulation in the circulation of a specific group of oxidized phospholipids (oxPC_CD36) that are ligands for the platelet pattern recognition receptor CD36. In the current article, we tested whether the platelet innate immune system contributes to responses to oxPC_CD36 and accelerated thrombosis observed in hyperlipidemia.

Methods and results

Using in vitro approaches, as well as platelets

SUBMITTER: Biswas S 

PROVIDER: S-EPMC5623081 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature