Mast Cells Granular Contents Are Crucial for Deep Vein Thrombosis in Mice.

ABSTRACT:

Rationale

Deep vein thrombosis (DVT) and its complication pulmonary embolism have high morbidity reducing quality of life and leading to death. Cellular mechanisms of DVT initiation remain poorly understood.

Objective

We sought to determine the role of mast cells (MCs) in DVT initiation and validate MCs as a potential target for DVT prevention.

Methods and results

In a mouse model, DVT was induced by partial ligation (stenosis) of the inferior vena cava. We demonstrated that 2 strains of mice deficient for MCs were completely protected from DVT. Adoptive transfer of in vitro differentiated MCs restored thrombosis. MCs were present in the venous wall, and the number of granule-containing MCs decreased with thrombosis. Pharmacological depletion of MCs granules or preven

SUBMITTER: Ponomaryov T 

PROVIDER: S-EPMC5623089 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature