Association Between Proton Pump Inhibitor Use and Cognitive Function in Women.

ABSTRACT:

Background & aims

Studies have reported associations between proton pump inhibitor (PPI) use and dementia. However, data are lacking on long-term PPI use and cognitive function. We therefore examined associations between PPI use and performance in tests of cognitive function. Because of shared clinical indications, we examined associations for H2 receptor antagonists (H2RAs) as a secondary aim.

Methods

We used prospectively collected data on medication use and other potential risk factors from 13,864 participants in the Nurses' Health Study II who had completed a self-administered computerized neuropsychological test battery. Multivariable linear regression models were used to examine associations between medication use and composite scores of psychomotor speed and attention

SUBMITTER: Lochhead P 

PROVIDER: S-EPMC5623145 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature