Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Background

Recent genome-wide association studies have identified 2 genetic polymorphisms in association with nonalcoholic fatty liver disease (NAFLD): patatin-like phospholipase domain containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), both of which appear to influence the production of very low density lipoprotein (VLDL). The impact of these genetic variations on lipoprotein metabolism in the setting of nonalcoholic steatohepatitis and liver fibrosis are not fully characterized.

Materials and methods

We measured comprehensive lipoprotein profiles by nuclear magnetic resonance among 170 serially recruited patients in an NAFLD registry, and determined their relationships with PNPLA3 and TM6SF2 genotypes.

Results

In this cohort, 72% patients had a

SUBMITTER: Jiang ZG 

PROVIDER: S-EPMC5623166 | biostudies-literature | 2018 May/Jun

REPOSITORIES: biostudies-literature