β₂ integrins rather than β₁ integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung.

ABSTRACT:

Background

Group 2 innate lymphoid cells (ILC2s) expand in the lungs of mice during type 2 inflammation induced by the fungal allergen Alternaria alternata. The increase in ILC2 numbers in the lung has been largely attributed to local proliferation and whether ILC2s migrate from the circulation to the lung after Alternaria exposure is unknown.

Objective

We examined whether human (lung, lymph node, and blood) and mouse lung ILC2s express β₁ and β₂ integrin adhesion molecules and whether these integrins are required for trafficking of ILC2s into the lungs of mice.

Methods

Human and mouse ILC2s were assessed for surface expression of β₁ and β₂ integrin adhesion molecules by using flow cytometry. The role of β₁ and β<

SUBMITTER: Karta MR 

PROVIDER: S-EPMC5623168 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature