Multi-scale immunoepidemiological modeling of within-host and between-host HIV dynamics: systematic review of mathematical models.

ABSTRACT:

Objective

The objective of this study is to conduct a systematic review of multi-scale HIV immunoepidemiological models to improve our understanding of the synergistic impact between the HIV viral-immune dynamics at the individual level and HIV transmission dynamics at the population level.

Background

While within-host and between-host models of HIV dynamics have been well studied at a single scale, connecting the immunological and epidemiological scales through multi-scale models is an emerging method to infer the synergistic dynamics of HIV at the individual and population levels.

Methods

We reviewed nine articles using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework that focused on the synergistic dynamics of HIV immunoepid

SUBMITTER: Dorratoltaj N 

PROVIDER: S-EPMC5623312 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature