Association between COL11A1 (rs1337185) and ADAMTS5 (rs162509) gene polymorphisms and lumbar spine pathologies in Chinese Han population: an observational study.

ABSTRACT:

Objectives

A previous study identified a significant association between several single nucleotide polymorphisms (SNPs) and lumbar disc degeneration (LDD) in Indians. To validate the association between these SNPs and specific lumbar spine pathologies, we performed a case-control study in Chinese Han population.

Design

An observational study.

Setting

University Hospital in Nanning, China.

Participants

This study included 428 patients with LDD and 400 normal controls.

Outcome measures

Patients with LDD were classified into four subgroups, including disc herniation only (subgroup 1), discopathies or/and osteochondrosis associated with disc herniation (subgroup 2), spinal stenosis or/and spondylolisthesis (subgroup 3) and degenerative scoliosis (subgroup 4)

SUBMITTER: Jiang H 

PROVIDER: S-EPMC5623369 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature