Pharmacological and non-pharmacological treatments for major depressive disorder: review of systematic reviews.

ABSTRACT:

Objectives

This study aims to summarise the evidence on more than 140 pharmacological and non-pharmacological treatment options for major depressive disorder (MDD) and to evaluate the confidence that patients and clinicians can have in the underlying science about their effects.

Design

This is a review of systematic reviews.

Data sources

This study used MEDLINE, Embase, Cochrane Library, PsycINFO and Epistemonikos from 2011 up to February 2017 for systematic reviews of randomised controlled trials in adult patients with acute-phase MDD.

Methods

We dually reviewed abstracts and full-text articles, rated the risk of bias of eligible systematic reviews and graded the strength of evidence.

Results

Nineteen systematic reviews provided data on 28 comparisons o

SUBMITTER: Gartlehner G 

PROVIDER: S-EPMC5623437 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature