Publication of interventional phase 3 and 4 clinical trials in radiation oncology: an observational study.

ABSTRACT:

Objectives

Clinical trials produce the best data available for decision-making in modern evidence-based medicine. We aimed to determine the rate of non-publication of interventional phase 3 and 4 clinical trials involving patients with cancer undergoing radiotherapy.

Setting

The ClinicalTrials.gov database was searched for interventional phase 3 and 4 trials in radiotherapy with a primary completion date before 1 January 2013. We determined how many of these registry entries have not published the compulsory deposition of their results in the database and performed a systematic search for published studies in peer-reviewed journals.

Results

Of 576 trials, 484 (84.0%) did not deposit a summary result in the registry. In addition, 44.9% of them did not publish their res

SUBMITTER: Perez-Alija J 

PROVIDER: S-EPMC5623516 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature