Urine cytology screening of French workers exposed to occupational urinary tract carcinogens: a prospective cohort study over a 20-year period.

ABSTRACT:

Objectives

To demonstrate that urine cytology screening can provide relevant epidemiological data for earlier detection of urothelial cancer caused by occupational exposure.

Design

Prospective cohort study.

Setting

Industries using urothelial carcinogens in France. Urine samples were collected on site, after a work week and were analysed at the University Hospital of Clermont-Ferrand, France.

Participants

Participants were workers exposed to urothelial carcinogens. Women and current smokers at time of study recruitment were exclusion criteria.

Outcomes

Urine cells atypia were ranged into three classes: negative/normal, atypical/suspicious/dysplasia or positive/malignant.

Results

We included 2020 workers over a period of 20 years from 1993 to 2013:

SUBMITTER: Dutheil F 

PROVIDER: S-EPMC5623560 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature