Thiazide diuretics and the risk of hip fracture after stroke: a population-based propensity-matched cohort study using Taiwan's National Health Insurance Research Database.

ABSTRACT:

Objectives

This study aimed to investigate the association between thiazide use and the risk of hip fracture after stroke.

Setting

A population-based, propensity-matched cohort study was conducted on the basis of Taiwan's National Health Insurance Research Database.

Participants

Patients with newly diagnosed ischaemic stroke between 2000 and 2011 were included. After propensity score matching, 7470 patients were included, of whom 3735 received thiazides and 3735 did not.

Outcome measures

HRs for developing hip fractures within 2 years after stroke were calculated using Cox proportional hazards regression model with adjustments for sociodemographic and coexisting medical conditions.

Results

Overall, patients using thiazides after stroke had a lower risk o

SUBMITTER: Lin SM 

PROVIDER: S-EPMC5623561 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature