Phthalate and bisphenol A exposure during in utero windows of susceptibility in relation to reproductive hormones and pubertal development in girls.

ABSTRACT:

Background

Over the past several decades, the age of pubertal onset in girls has shifted downward worldwide. As early pubertal onset is associated with increased risky behavior and psychological issues during adolescence and cardiometabolic disease and cancer in adulthood, this is an important public health concern. Exposure to endocrine disrupting chemicals during critical windows of in utero development may play a role in this trend. Our objective was to investigate trimester-specific phthalate and BPA exposure in relation to pubertal development among girls in the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort.

Methods

We measured maternal urinary phthalate metabolites and BPA in samples collected during the first, second, and third trimes

SUBMITTER: Watkins DJ 

PROVIDER: S-EPMC5623649 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature