Sex Differences of Human Cardiac Progenitor Cells in the Biological Response to TNF-α Treatment.

ABSTRACT: Adult cardiac progenitor cells (CPCs), isolated as cardiosphere-derived cells (CDCs), represent promising candidates for cardiac regenerative therapy. CDCs can be expanded in vitro manyfolds without losing their differentiation potential, reaching numbers that are appropriate for clinical applications. Since mechanisms of successful CDC survival and engraftment in the damaged myocardium are still critical and unresolved issues, we aimed at deciphering possible key factors capable of bolstering CDC function. In particular, the response and the phenotype of CDCs exposed to low concentrations of the multifunctional cytokine tumor necrosis factor α (TNF-α), known to be capable of activating cell survival pathways, have been investigated. Furthermore, differential biological respo

SUBMITTER: Straface E 

PROVIDER: S-EPMC5623773 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature