Prognostic and functional role of subtype-specific tumor-stroma interaction in breast cancer.

ABSTRACT: None of the clinically relevant gene expression signatures available for breast cancer were specifically developed to capture the influence of the microenvironment on tumor cells. Here, we attempted to build subtype-specific signatures derived from an in vitro model reproducing tumor cell modifications after interaction with activated or normal stromal cells. Gene expression signatures derived from HER2+, luminal, and basal breast cancer cell lines (treated by normal fibroblasts or cancer-associated fibroblasts conditioned media) were evaluated in clinical tumors by in silico analysis on published gene expression profiles (GEPs). Patients were classified as microenvironment-positive (μENV+ve), that is, with tumors showing molecular profiles suggesting activation by the stroma, or microenvi

SUBMITTER: Merlino G 

PROVIDER: S-EPMC5623822 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature