Circulating Cholesterol Levels May Link to the Factors Influencing Parkinson's Risk.

ABSTRACT:

Objectives

A growing literature suggests that circulating cholesterol levels have been associated with Parkinson's disease (PD). In this study, we investigated a possible causal basis for the cholesterol-PD link.

Methods

Fasting plasma cholesterol levels were obtained from 91 PD and 70 age- and gender-matched controls from an NINDS PD Biomarkers Program cohort at the Pennsylvania State University College of Medicine. Based on the literature, genetic polymorphisms in selected cholesterol management genes (APOE, LDLR, LRP1, and LRPAP1) were chosen as confounding variables because they may influence both cholesterol levels and PD risk. First, the marginal structure model was applied, where the associations of total- and LDL-cholesterol levels with genetic polymorphisms, statin

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5624032 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature