Characterization of Mycobacterium tuberculosis-Specific Cells Using MHC Class II Tetramers Reveals Phenotypic Differences Related to HIV Infection and Tuberculosis Disease.

ABSTRACT: A major challenge for the development of an effective vaccine against tuberculosis (TB) is that the attributes of protective CD4⁺ T cell responses are still elusive for human TB. Infection with HIV type 1 is a major risk factor for TB, and a better understanding of HIV-induced alterations of Mycobacterium tuberculosis-specific CD4⁺ T cells that leads to failed host resistance may provide insight into protective T cell immunity to TB. A total of 86 participants from a TB-endemic setting, either HIV-infected or uninfected and with latent or active TB (aTB), were screened using M.tuberculosis-specific MHC class II tetramers. We examined the phenotype as well as function of ex vivo M. tuberculosis-specific tetramer⁺CD4⁺ T

SUBMITTER: Strickland N 

PROVIDER: S-EPMC5624500 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature