Implication of the neurotrophin receptor p75^NTR in vascular diseases: beyond the eye.

ABSTRACT:

Introduction

The p75 neurotrophin receptor (p75^NTR) is a member of TNF-α receptor superfamily that bind all neurotrophins, mainly regulating their pro-apoptotic actions. Ischemia is a common pathology in different cardiovascular diseases affecting multiple organs, however the contribution of p75^NTR remains not fully addressed. The aim of this work is to review the current evidence through published literature studying the impact of p75^NTR receptor in ischemic vascular diseases.

Areas covered

In the eye, several ischemic ocular diseases are associated with enhanced p75^NTR expression. Ischemic retinopathy including diabetic retinopathy, retinopathy of prematurity and retinal vein occlusion are characterized initially by ischemia foll

SUBMITTER: Elshaer SL 

PROVIDER: S-EPMC5624543 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature