Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a common complication of chronic viral hepatitis. In support of this notion, we have reported that hepatitis B surface antigen (HBsAg)-specific CD8+ T lymphocytes critically contribute to inducing chronic liver cell injury that exerts high carcinogenic potential in a hepatitis B virus (HBV) transgenic mouse model. The dynamics of the molecular signatures responsible for hepatocellular carcinogenesis are not fully understood. The current study was designed to determine the serial changes in gene expression profiles in a model of chronic immune-mediated hepatitis.

Methods

Three-month-old HBV transgenic mice were immunologically reconstituted with bone marrow cells and splenocytes from syngeneic nontransgenic donors. Liver tissues we

SUBMITTER: Nosaka T 

PROVIDER: S-EPMC5624708 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature