Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II.

ABSTRACT: The activation of T helper cells requires antigens to be exposed on the surface of antigen presenting cells (APCs) via MHC class II (MHC-II) molecules. Expression of MHC-II is generally limited to professional APCs, but other cell types can express MHC-II under inflammatory conditions. However, the importance of these conditional APCs is unknown. We and others have previously shown that Schwann cells are potentially conditional APCs, but the functional relevance of MHC-II expression by Schwann cells has not been studied in vivo. Here, we conditionally deleted the MHC-II β-chain from myelinating Schwann cells in mice and investigated how this influenced post-traumatic intraneural inflammation and neuropathic pain using the chronic constriction injury (CCI) model. We demonstrate that deletio

SUBMITTER: Hartlehnert M 

PROVIDER: S-EPMC5624882 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature