Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children.

ABSTRACT: Protective antibody levels are critical for protection from severe enterovirus 71 infection. However, little is known about the specificities and functional properties of the enterovirus 71-specific antibodies induced by natural infection in humans. Here we characterize 191 plasmablast-derived monoclonal antibodies from three enterovirus 71-infected children, each of whom shows a distinct serological response. Of the 84 enterovirus 71-specific antibodies, neutralizing antibodies that target the rims and floor of the capsid canyon exhibit broad and potent activities at the nanogram level against viruses isolated in 1998-2016. We also find a subset of infected children whose enterovirus 71-specific antibodies are focused on the 3- and 2-fold plateau epitopes localized at the margin of pentam

SUBMITTER: Arthur Huang KY 

PROVIDER: S-EPMC5624920 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature