Marginal structural model to evaluate the association between cumulative osteoporosis medication and infection using claims data.

ABSTRACT: Due to the suboptimal persistence to osteoporosis (OP) treatment, factors triggering treatment discontinuation/switching may be causing time-varying confounding. BP treatment was associated with the risk of overall infection in opposite directions in the unweighted Cox model versus the weighted MSM. The discrepancy of effect estimates for overall infection in the MSM suggested there may be time-varying confounding.

Introduction

Due to the suboptimal persistence to osteoporosis (OP) treatment, factors triggering treatment discontinuation/switching may be affected by prior treatment and confound the subsequent treatment effect, causing time-varying confounding.

Methods

In a US insurance database, the association between joint treatment of bisphosphonates (BP) and other OP medic

SUBMITTER: Xue F 

PROVIDER: S-EPMC5624978 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature