The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line.

ABSTRACT: The OK cell line derived from the kidney of a female opossum Didelphis virginiana has proven to be a useful model in which to investigate the unique regulation of ion transport and membrane trafficking mechanisms in the proximal tubule (PT). Sequence data and comparison of the transcriptome of this cell line to eutherian mammal PTs would further broaden the utility of this culture model. However, the genomic sequence for D. virginiana is not available and although a draft genome sequence for the opossum Monodelphis domestica (sequenced in 2012 by the Broad Institute) exists, transcripts sequenced from both species show significant divergence. The M. domestica sequence is not highly annotated, and the majority of transcripts are predicted rather than experimental

SUBMITTER: Eshbach ML 

PROVIDER: S-EPMC5625107 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature