Analysis of sphingolipids, sterols, and phospholipids in human pathogenic Cryptococcus strains.

ABSTRACT: Cryptococcus species cause invasive infections in humans. Lipids play an important role in the progression of these infections. Independent studies done by our group and others provide some detail about the functions of these lipids in Cryptococcus infections. However, the pathways of biosynthesis and the metabolism of these lipids are not completely understood. To thoroughly understand the physiological role of these Cryptococcus lipids, a proper structure and composition analysis of Cryptococcus lipids is demanded. In this study, a detailed spectroscopic analysis of lipid extracts from Cryptococcus gattii and Cryptococcus grubii strains is presented. Sphingolipid profiling by LC-ESI-MS/MS was used to analyze sphingosine, dihydrosphingosine, sphin

SUBMITTER: Singh A 

PROVIDER: S-EPMC5625125 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature