Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury.

ABSTRACT: Two populations of alveolar macrophages (AMs) coexist in the inflamed lung: resident AMs that arise during embryogenesis, and recruited AMs that originate postnatally from circulating monocytes. The objective of this study was to determine whether origin or environment dictates the transcriptional, metabolic, and functional programming of these two ontologically distinct populations over the time course of acute inflammation. RNA sequencing demonstrated marked transcriptional differences between resident and recruited AMs affecting three main areas: proliferation, inflammatory signaling, and metabolism. Functional assays and metabolomic studies confirmed these differences and demonstrated that resident AMs proliferate locally and are governed by increased tricarboxylic acid cycle and amino

SUBMITTER: Mould KJ 

PROVIDER: S-EPMC5625228 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature