Brain Responses to Smoking Cues Differ Based on Nicotine Metabolism Rate.

ABSTRACT:

Background

Inherited differences in the rate of metabolism of nicotine, the addictive chemical in tobacco, affect smoking behavior and quitting success. The nicotine metabolite ratio (3'-hydroxycotinine/cotinine) is a reliable measure of nicotine clearance and a well-validated predictive biomarker of response to pharmacotherapy. To clarify the mechanisms underlying these associations, we investigated the neural responses to smoking cues in normal and slow nicotine metabolizers.

Methods

Treatment-seeking smokers (N = 69; 30 slow metabolizers and 39 normal metabolizers) completed a visual cue reactivity task during functional magnetic resonance imaging on two separate occasions: once during smoking satiety and once after 24 hours of smoking abstinence.

Results

In whole-

SUBMITTER: Falcone M 

PROVIDER: S-EPMC5625335 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature