Impact of mesenchymal stem cells' secretome on glioblastoma pathophysiology.

ABSTRACT:

Background

Glioblastoma (GBM) is a highly aggressive primary brain cancer, for which curative therapies are not available. An emerging therapeutic approach suggested to have potential to target malignant gliomas has been based on the use of multipotent mesenchymal stem cells (MSCs), either unmodified or engineered to deliver anticancer therapeutic agents, as these cells present an intrinsic capacity to migrate towards malignant tumors. Nevertheless, it is still controversial whether this innate tropism of MSCs towards the tumor area is associated with cancer promotion or suppression. Considering that one of the major mechanisms by which MSCs interact with and modulate tumor cells is via secreted factors, we studied how the secretome of MSCs modulates critical hallmark features of G

SUBMITTER: Vieira de Castro J 

PROVIDER: S-EPMC5625623 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature